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修改名片 : CAR T

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CAR T

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There’re four generations of CAR products available in Creative-biolabs. The first generation CAR consisting of basic elements has been widely applied in early cancer immunotherapy clinical trials. Different from the first generation which has one intracellular signaling domain like CD3ζ or or FcεRIγ, our second-generation CAR is composed of an activating domain plus a co-stimulatory signal domain such as CD28 or 4-1BB, the structure of which can support longer antitumor effect. Similar to this strategy, two different co-stimulatory signaling regions are constructed into the third generation CARs in order to promote the T cell activation signal and enhance the proliferation and survival of CAR-T cells significantly. Furthermore, the fourth generation CAR construct is engineered with an inducible expression unit such as a cytokine (like IL-12), which can effectively overcome the “on-target, off-tumor” drawbacks via this inducible transgenic cytokine gene.

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